Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. Assuming you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you might be wondering what caused the loss and worry about whether it’ll happen again. This short article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
Which kind of genetic testing is available for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most typical cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a child to develop normally it is important that it have exactly the right quantity of chromosome material; missing or extra material at the time of conception or within an embryo or fetus could cause a female to either not become pregnant, miscarry, or have a child with a chromosome syndrome such as Down syndrome.

Over 50% of most first trimester miscarriages are due to chromosome abnormalities. This number could be closer to 75% or higher for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is far more common than most people think. infant loss Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The chance of experiencing a miscarriage also increases as a mother ages.

Most women who experience a miscarriage go on to have a healthy pregnancy and never miscarry again. However, some women appear to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage is apparently increasing. One reason for this can be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas in the past the miscarriage would have were just an unusual period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Helpful for Miscarriages

Genetic testing actually identifies many different types of testing that can be done on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), the most useful type of test to execute is really a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the current presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue can often identify the reason behind the pregnancy loss.

The most common method of chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, a process called “cell culture”. Due to this requirement, tissue that is passed at home is often unable to be tested with this method. About 20% or more of miscarriage samples fail to grow and thus no email address details are available. Additionally, karyotyping struggles to tell the difference between cells from the mother (maternal cells) and cells from the fetus. If a normal female result is available, it may be the right result for the fetus or it might be maternal cell contamination (MCC) where the result actually comes from testing the mother’s cells present in the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or more of the samples tested by traditional karyotype. Results from karyotyping usually have a few weeks to months another from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; both most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing can be in a position to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you are more prone to receive results and the outcomes are typically returned faster when microarray testing can be used. Additionally, some laboratories are collecting a sample of the mother’s blood as well the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How do it help?

In case a chromosome abnormality is identified, the kind of abnormality found can be assessed to help answer the question: “Will this eventually me again?”. Quite often, chromosome abnormalities within an embryo or fetus aren’t inherited and have a low chance to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your doctor to do further studies to research the chance of an underlying genetic or chromosome problem in your loved ones that predisposes you to have miscarriages.

Furthermore, in case a chromosome abnormality is identified it can prevent the need for other, sometimes quite costly, studies your physician might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason behind a pregnancy loss can help a couple of start the emotional healing process, moving at night question of “Why did this eventually me?”.

Chromosome testing could be especially very important to patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason for the miscarriages and invite their doctor to pursue other styles of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their chances of having a successful healthy pregnancy.

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