Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

Although most couples are blissfully unacquainted with the statistics surrounding miscarriage, pregnancy loss is really quite common, with 10-25% of recognized pregnancies ending in miscarriage. In case you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you could be wondering what caused losing and worry about whether it will happen again. This short article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing can be acquired for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most typical cause for first trimester miscarriage is really a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes which come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a baby to develop normally it is crucial that it have exactly the right level of chromosome material; missing or extra material at the time of conception or in an embryo or fetus can cause a female to either not become pregnant, miscarry, or have a baby with a chromosome syndrome such as Down syndrome.

pregnancy loss Over 50% of all first trimester miscarriages are caused by chromosome abnormalities. This number could be closer to 75% or more for women aged 35 years and over who have experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is a lot more common than most people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of having a miscarriage also increases as a mother ages.

Most women who experience a miscarriage go on to have a healthy pregnancy rather than miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this can be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas in the past the miscarriage would have were just an unusual period. Another reason may be that more women are conceiving at older ages.

Types of Genetic Testing Helpful for Miscarriages

Genetic testing actually refers to many different types of testing that you can do on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), the most useful type of test to execute is really a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common approach to chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For this reason requirement, tissue that’s passed at home is frequently unable to be tested with this particular method. About 20% or even more of miscarriage samples fail to grow and thus no email address details are available. Additionally, karyotyping struggles to tell the difference between cells from mom (maternal cells) and cells from the fetus. In case a normal female result is available, it may be the correct result for the fetus or it could be maternal cell contamination (MCC) in which the result actually originates from testing the mother’s cells within the pregnancy tissue rather than the fetal cells. MCC seems to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months to come back from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also in a position to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you are more prone to receive results and the outcomes are usually returned faster when microarray testing can be used. Additionally, some laboratories are collecting a sample of the mother’s blood concurrently the miscarriage tissue is delivered to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

If a chromosome abnormality is identified, the sort of abnormality found could be assessed to help answer the question: “Will this happen to me again?”. More often than not, chromosome abnormalities within an embryo or fetus aren’t inherited and have a minimal chance to occur in future pregnancies. Sometimes, a specific chromosome finding in a miscarriage alerts your doctor to do further studies to research the possibility of an underlying genetic or chromosome problem in your family that predisposes one to have miscarriages.

Furthermore, in case a chromosome abnormality is identified it could prevent the need for other, sometimes quite costly, studies your doctor might consider to investigate the reason for the miscarriage.

Lastly, knowing the reason behind a pregnancy loss might help a couple start the emotional healing process, moving past the question of “Why did this eventually me?”.

Chromosome testing can be especially important for patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason behind the miscarriages and invite their doctor to pursue other types of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their likelihood of having a successful healthy pregnancy.

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